Best Ergonomic Mice to Prevent Injuries and Improve Comfort in 2025
Check out the best ergonomic mice to prevent injuries and improve comfort during prolonged use in 2025.
If you spend many hours at the computer, you've probably felt that discomfort in your wrist or forearm after a long day of work. I also went through this until I discovered the difference an ergonomic mouse can make in my daily routine.
After testing various models and talking with physiotherapists specialized in RSI/WMSD, I prepared this complete guide with the best ergonomic mice of 2025. Each model was selected thinking about comfort, injury prevention, and build quality.
If you work from home or spend long hours at the computer, keep reading to discover which mouse can transform your user experience and protect your health.
Logitech MX Vertical Ergonomic Mouse

- Vertical design with 57° angle
- Adjustable 4000 DPI optical sensor
- USB-C and Bluetooth connectivity
- Battery lasting up to 4 months
- Compatible with Windows and Mac
- Customizable programmable buttons
Logitech's MX Vertical is considered by many the gold standard of ergonomic mice. Its vertical design drastically reduces muscle pressure on the wrist, while the high-precision sensor ensures smooth and accurate movements. Ideal for professionals who demand comfort and performance.
Anker Vertical Ergonomic Mouse

- Vertical design for natural wrist position
- 1600 DPI optical sensor
- 2.4GHz wireless connection
- 6 functional buttons
- Extended battery life
- Integrated thumb rest
Anker offers an excellent option for those seeking ergonomics without compromising the budget. This vertical mouse provides a natural and comfortable grip, reducing wrist tension during long work sessions. Perfect for beginners in the world of ergonomic mice.
Microsoft Sculpt Ergonomic Mouse

- Natural curved design
- BlueTrack technology
- Reliable wireless connection
- Detachable thumb rest
- Horizontal and vertical scroll wheel
- Universal compatibility
Microsoft's Sculpt brings a unique design that perfectly adapts to the hand shape. Unlike vertical models, it maintains a more familiar position while offering ergonomic support. Ideal for those who want to start a gradual transition to more ergonomic equipment.
TeckNet Vertical Ergonomic Mouse

- 90° vertical position
- 3 adjustable DPI levels
- 2.4GHz wireless connection
- USB rechargeable battery
- Ambidextrous design
- Non-slip textured surface
An affordable option without sacrificing quality, TeckNet offers complete vertical design for maximum ergonomic comfort. Its robust construction and long-lasting battery make it a smart choice for home and professional use.
How to Choose the Ideal Ergonomic Mouse for You
For Ergonomics Beginners
If you've never used an ergonomic mouse, the Microsoft Sculpt is an excellent entry point. It offers ergonomic benefits while maintaining a familiar grip, making adaptation easier.
For Intensive Professional Use
Professionals who spend more than 8 hours daily at the computer will benefit greatly from the Logitech MX Vertical. Its superior precision and comfort justify the investment in occupational health.
For Limited Budget
The TeckNet and Anker models offer excellent cost-benefit, providing ergonomic relief without compromising family or business budget.
For Mobile Users
The Jelly Comb with dual connectivity is perfect for those working with multiple devices or needing a portable mouse for travel.
Benefits of Ergonomic Mice
Injury Prevention
Ergonomic mice significantly reduce the risk of developing RSI/WMSD, carpal tunnel syndrome, and tendinitis. The natural wrist position decreases pressure on nerves and tendons.
Productivity Improvement
With less muscle fatigue, you maintain focus longer and execute tasks with greater precision. Many users report noticeable improvement in work quality.
Lasting Comfort
The difference in comfort becomes evident within the first hours of use, especially for those who already felt discomfort with conventional mice.
Adaptation Tips
Adjustment Period
Set aside 1 to 2 weeks for complete adaptation. It's normal to feel initial strangeness, but the benefits soon become evident.
Correct Positioning
Keep your arm relaxed and close to your body. The table height should allow your elbow to form a 90° angle.
Combine with Other Equipment
For maximum benefit, also consider an ergonomic keyboard and proper monitor support.
Conclusion: Which Ergonomic Mouse to Choose in 2025?
The choice of the ideal ergonomic mouse depends on your specific needs and available budget. Our general recommendation is:
- Best overall cost-benefit: Anker Vertical Mouse
- Best for beginners: Microsoft Sculpt Ergonomic
- Best premium ergonomic mouse: Logitech MX Vertical
Regardless of your choice, any of these ergonomic mice will provide significant benefits for your health and comfort during work. Investment in ergonomics is always an investment in your long-term well-being.